TB-500
aka Thymosin Beta-4 fragment
Lab-made copy of the working part of a natural healing protein (Thymosin Beta-4).
Technically · Synthetic peptide (Thymosin Beta-4 fragment)
In one sentence
BPC-157's recovery partner — drives cell migration to injury sites so tissue rebuilds faster.
— Think of it as a traffic cop that sends repair crews wherever your body is hurt.
Half-life
~2 hours
About 2 hours active — dosed a couple times per week.
Dosing
Loading: 2× weekly for 4 weeks. Maintenance: 1× weekly for 4 weeks.
How often you take a dose
Route
SubQ · IM
How it goes into the body
Status
Research
Sold for lab research — not approved for humans
What it is
Your body makes a protein called Thymosin Beta-4 that helps tissue repair itself. TB-500 is the synthetic copy of the active piece. Used alongside BPC-157 for tendon, ligament, and soft-tissue healing. Like BPC-157, there are no published human trials yet.
The full technical answer
Synthetic version of the active region of thymosin beta-4. Studied alongside BPC-157 for soft tissue repair. No published human RCTs.
How it works
It helps cells move to where the damage is, builds new blood vessels at injury sites, and speeds up tissue regrowth. Think of it as the GPS that routes healing cells where they're needed.
The full technical answer
Animal studies suggest it promotes actin sequestration, cell migration, and angiogenesis — useful for wound healing and tissue regeneration.
What the research says
Animal studies show accelerated wound healing and cardiac repair. Used clinically in veterinary medicine. No human RCTs published.
Sources: PubMed: TB-500
Common dosing ranges
- Range
- 1–2 mg per dose (anecdotal protocols)
- Frequency
- Loading: 2× weekly for 4 weeks. Maintenance: 1× weekly for 4 weeks.
- Duration
- 8 weeks typical
Sources: PubMed reviews
How to take it
Practical guidance synthesized from clinical protocols, FDA labels, and clinician interviews. Always cross-check with a prescribing physician.
Best time of day
AM is typical. Some users experience post-injection lethargy — schedule accordingly.
With food or fasted
Doesn't matter for SubQ or IM injection.
How long to cycle
Loading phase: 2× per week for 4 weeks. Maintenance: 1× per week for another 4 weeks. Total 8 weeks per cycle.
When to get off
End each 8-week cycle. Allow at least 4 weeks rest before next cycle. Stop entirely if any active or suspected cancer (theoretical angiogenesis risk).
Administration
Side effects
Common
- Lethargy after injection
- Injection site reaction
Serious / theoretical
- Unknown long-term human safety; theoretical concern with active malignancy due to angiogenesis
Sources: PubMed
Notes
FDA placed TB-500 on the 503A "Category 2" bulks list in 2023.
Further reading & listening
Where the experts go deeper.
Curated from the PeptideFacts expert directory — vetted YouTube channels, podcasts, books, and communities. No anecdote-only or supplier-affiliated picks.
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