Research only·Tripeptide anti-inflammatory

KPV

aka α-MSH (11-13)

Education only. Many compounds discussed are research chemicals not approved for human use in the US. This is not medical advice — consult a licensed physician.

What it is

A three-amino-acid C-terminal fragment of α-melanocyte-stimulating hormone (Lys-Pro-Val). Acts as an NFκB blocker — the master inflammation switch. Used for autoimmune calming and gut healing.

How it works

Blocks NFκB transcription factor activation, reducing pro-inflammatory cytokine cascades. Hunter Williams describes it as a "fire extinguisher" for inflammation versus BPC-157's "construction crew" repair.

What the research says

Animal and in-vitro data for inflammatory bowel disease, allergic inflammation, and autoimmune calming. Limited human RCTs. Strong anecdotal data in peptide community for gut and skin inflammation.

Sources: PubMed: KPV anti-inflammatory

Common dosing ranges

Range: 200–500 mcg/day
Frequency: Daily SubQ; can stack with BPC-157/TB-500
Duration: 4–6 weeks on / 2–4 weeks off (Bachmeyer)

Sources: PubMed

Administration

SubQ · Oral

Half-life

Short (hours)

Side effects

Common

Generally well-tolerated
Minimal reported

Serious / theoretical

Long-term safety in healthy users not established

Sources: PubMed

Notes

Hunter Williams rates KPV above BPC-157 specifically for inflammation. Stacks with BPC-157 + TB-500 in advanced gut/autoimmune protocols.