SLU-PP-332
A small molecule (not really a peptide) that flips the metabolic switch your body uses during cardio.
Technically · ERRα agonist (exercise mimetic)
In one sentence
A small molecule that flips the metabolic switch your body uses during cardio — without the cardio.
— Like running 5 miles, except it's a shot and you sit on the couch. Mouse data only — humans are TBD.
Half-life
1–2 hours (short)
Short — 1-2 hours. Used only on workout days, split-dosed.
Dosing
Workout days only — fasted AM or post-workout; split doses (1–2 hr half-life)
How often you take a dose
Route
SubQ
How it goes into the body
Status
Investigational
Still in clinical trials, not on the market
What it is
Technically not a peptide — it's a small molecule that activates ERRα, the master switch your body flips when you exercise. In mice, it boosts endurance ~70% and burns more fat without any actual exercise. No human trials yet. Strong "looks like a cheat code" energy, but the human data simply doesn't exist.
The full technical answer
A small molecule (not technically a peptide) that activates estrogen-related receptor alpha (ERRα), the master switch for oxidative metabolism. Animal data shows ~70% endurance increase, ~23% fat oxidation increase, mitochondrial biogenesis without exercise.
How it works
When you run, your cells flip an internal switch (ERRα) that says "burn fat for fuel, grow more mitochondria, get more efficient." SLU-PP-332 flips that same switch chemically — so your cells act like you've been training, even if you haven't.
The full technical answer
Binds and activates ERRα, which transcriptionally upregulates oxidative phosphorylation, mitochondrial biogenesis, and fat oxidation pathways. Effectively shifts cellular metabolism toward fat-burning mode independent of exercise stimulus.
What the research says
Animal studies only — no human RCT data exists. Strong mouse data for endurance and fat oxidation. Castore (EliteFTS) explicitly calls animal-to-human dose conversion unreliable. Use with this awareness.
Sources: PubMed: SLU-PP-332
Common dosing ranges
- Range
- 100 mcg start; sweet spot 200 mcg 2x/day; max ~1 mg/day injectable
- Frequency
- Workout days only — fasted AM or post-workout; split doses (1–2 hr half-life)
- Duration
- Short cycles; no established cycling protocol
Sources: PubMed
How to take it
Practical guidance synthesized from clinical protocols, FDA labels, and clinician interviews. Always cross-check with a prescribing physician.
Best time of day
WORKOUT DAYS ONLY — split dose: half pre-workout fasted, half post-workout. No signal to amplify on rest days.
With food or fasted
Fasted preferred. Carbs blunt the ERRα fat-burning signal.
How long to cycle
No established cycling protocol — short cycles only. Castore (EliteFTS) recommends keeping cycles brief due to lack of human safety data.
When to get off
Brain fog, fatigue wall, or any GI side effects → pause. NEVER combine with BAM-15 (mitochondrial damage reports).
Administration
Side effects
Common
- Brain fog at high doses (neuronal glucose depletion)
- Fatigue wall
Serious / theoretical
- NEVER combine with BAM-15 — mitochondrial damage (Castore ICU report)
- Long-term safety unknown — no human trial data
Sources: PubMed
Notes
Oral version has negligible absorption — injectable only. Bachmeyer notes DMSO is required for solubility. Workout days only (Castore) — no signal to amplify on rest days.
Further reading & listening
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