Investigational·ERRα agonist (exercise mimetic)

SLU-PP-332

Education only. Many compounds discussed are research chemicals not approved for human use in the US. This is not medical advice — consult a licensed physician.

What it is

A small molecule (not technically a peptide) that activates estrogen-related receptor alpha (ERRα), the master switch for oxidative metabolism. Animal data shows ~70% endurance increase, ~23% fat oxidation increase, mitochondrial biogenesis without exercise.

How it works

Binds and activates ERRα, which transcriptionally upregulates oxidative phosphorylation, mitochondrial biogenesis, and fat oxidation pathways. Effectively shifts cellular metabolism toward fat-burning mode independent of exercise stimulus.

What the research says

Animal studies only — no human RCT data exists. Strong mouse data for endurance and fat oxidation. Castore (EliteFTS) explicitly calls animal-to-human dose conversion unreliable. Use with this awareness.

Sources: PubMed: SLU-PP-332

Common dosing ranges

Range: 100 mcg start; sweet spot 200 mcg 2x/day; max ~1 mg/day injectable
Frequency: Workout days only — fasted AM or post-workout; split doses (1–2 hr half-life)
Duration: Short cycles; no established cycling protocol

Sources: PubMed

Administration

SubQ

Half-life

1–2 hours (short)

Side effects

Common

Brain fog at high doses (neuronal glucose depletion)
Fatigue wall

Serious / theoretical

NEVER combine with BAM-15 — mitochondrial damage (Castore ICU report)
Long-term safety unknown — no human trial data

Sources: PubMed

Notes

Oral version has negligible absorption — injectable only. Bachmeyer notes DMSO is required for solubility. Workout days only (Castore) — no signal to amplify on rest days.