Klotho
aka α-Klotho protein
What it is
A protein produced primarily by the kidneys. Higher Klotho levels correlate strongly with longer healthspan in observational studies. Recombinant Klotho is now available via compounding pharmacies — Jay Campbell's 2026 standout longevity peptide.
How it works
Modulates FGF23 signaling, calcium-phosphate balance, insulin sensitivity, and TGF-β pathways. Endothelial protective. Crosses blood-brain barrier and shows neuroprotective effects in animal models.
What the research says
Strong observational data linking serum Klotho to longevity. Limited human RCT data on supplementation. Jay Campbell reports significant subjective improvement after 4 months — endothelial function, sleep, libido, mood. Albumin-bound version has 19-day half-life.
Sources: PubMed: Klotho longevity
Common dosing ranges
- Range
- 10 mcg per dose (albumin-bound)
- Frequency
- Every 2 weeks SubQ
- Duration
- Ongoing — long half-life means infrequent dosing
Sources: PubMed
Administration
SubQ
Half-life
~19 days (albumin-bound)
Side effects
Common
- Generally well-tolerated in early reports
Serious / theoretical
- Long-term human safety data not yet established
- Cost barrier (~$380/month) — verify source quality
Sources: PubMed
Notes
Jay Campbell calls it "the fountain of youth molecule" in 2026 podcasts. Tyna Moore notes secondary benefits for menstrual cycle regulation in some users (anecdotal).