Klotho
aka α-Klotho protein
A protein your kidneys make. People with more of it tend to live longer.
Technically · Anti-aging hormone / protein
In one sentence
A protein your kidneys make that strongly tracks with how long you'll live. New recombinant version dosed every 2 weeks.
— Like a longevity biomarker you can actually inject. Strong correlations, early human data, expensive.
Half-life
~19 days (albumin-bound)
The lab-made version lasts ~19 days. One shot every two weeks.
Dosing
Every 2 weeks SubQ
How often you take a dose
Route
SubQ
How it goes into the body
Status
Investigational
Still in clinical trials, not on the market
What it is
Klotho is a protein your kidneys produce naturally. Researchers noticed years ago that people with higher levels live longer healthier lives, with better heart, brain, and kidney function. A recombinant (lab-made) version is now available through compounding pharmacies. Long half-life means one shot every two weeks.
The full technical answer
A protein produced primarily by the kidneys. Higher Klotho levels correlate strongly with longer healthspan in observational studies. Recombinant Klotho is now available via compounding pharmacies — Jay Campbell's 2026 standout longevity peptide.
How it works
Klotho touches several systems at once: it regulates calcium and phosphate, helps your blood vessels stay flexible, modulates aging-related growth signals, and even crosses into the brain. Animal studies show neuroprotection. Early human data is encouraging but not conclusive.
The full technical answer
Modulates FGF23 signaling, calcium-phosphate balance, insulin sensitivity, and TGF-β pathways. Endothelial protective. Crosses blood-brain barrier and shows neuroprotective effects in animal models.
What the research says
Strong observational data linking serum Klotho to longevity. Limited human RCT data on supplementation. Jay Campbell reports significant subjective improvement after 4 months — endothelial function, sleep, libido, mood. Albumin-bound version has 19-day half-life.
Sources: PubMed: Klotho longevity
Common dosing ranges
- Range
- 10 mcg per dose (albumin-bound)
- Frequency
- Every 2 weeks SubQ
- Duration
- Ongoing — long half-life means infrequent dosing
Sources: PubMed
How to take it
Practical guidance synthesized from clinical protocols, FDA labels, and clinician interviews. Always cross-check with a prescribing physician.
Best time of day
Every 14 days, any time of day, any day of the week. Long half-life means a missed dose isn't catastrophic.
With food or fasted
Doesn't matter — SubQ injection.
How long to cycle
Ongoing. No established cycling protocol — most early users run it continuously.
When to get off
Cost barrier (~$380/month) is the most common stop reason. Any injection-site reaction or unusual symptoms → consult physician.
Administration
Side effects
Common
- Generally well-tolerated in early reports
Serious / theoretical
- Long-term human safety data not yet established
- Cost barrier (~$380/month) — verify source quality
Sources: PubMed
Notes
Jay Campbell calls it "the fountain of youth molecule" in 2026 podcasts. Tyna Moore notes secondary benefits for menstrual cycle regulation in some users (anecdotal).
Further reading & listening
Where the experts go deeper.
Curated from the PeptideFacts expert directory — vetted YouTube channels, podcasts, books, and communities. No anecdote-only or supplier-affiliated picks.