CJC-1295
aka DAC-GRF, CJC-1295 with DAC
A long-lasting version of the natural hormone that tells your pituitary to release growth hormone.
Technically · GHRH analog
In one sentence
Tells the pituitary to release growth hormone all week from a single injection — Ipamorelin's long-acting partner.
— Like setting your body's HGH thermostat higher and walking away. DAC version lasts ~8 days per shot.
Half-life
No-DAC: ~30 min. DAC: ~8 days.
The DAC version lasts ~8 days — one shot a week. No-DAC lasts 30 min — multiple shots a day.
Dosing
No-DAC: 1–3× daily. DAC: weekly.
How often you take a dose
Route
SubQ
How it goes into the body
Status
Research
Sold for lab research — not approved for humans
What it is
Your hypothalamus normally tells your pituitary "release growth hormone now" using a hormone called GHRH. CJC-1295 is a synthetic, longer-lasting copy of that signal. The "DAC" version sticks around for about 8 days — one shot a week is enough.
How it works
Think of CJC-1295 as setting your body's growth-hormone thermostat slightly higher all week. It binds the GHRH receptor on the pituitary, which keeps releasing natural pulses of GH on a steady background level — no forced spikes, just elevated baseline.
What the research says
Phase 1 PK study (Teichman 2006) confirmed GH/IGF-1 elevation. Long-term outcome trials lacking.
Sources: CJC-1295 PK study
Common dosing ranges
- Range
- No-DAC: 100 mcg with each Ipamorelin dose. DAC: 1–2 mg weekly.
- Frequency
- No-DAC: 1–3× daily. DAC: weekly.
- Duration
- 8–12 week cycles
Sources: PubMed
How to take it
Practical guidance synthesized from clinical protocols, FDA labels, and clinician interviews. Always cross-check with a prescribing physician.
Best time of day
No-DAC: before bed, fasted, paired with Ipamorelin. DAC: 1× per week, any day, time of day less critical due to long half-life.
With food or fasted
Fasted — at least 2 hours after last meal. Insulin blunts the GH pulse.
How long to cycle
8–12 weeks on, 4 weeks off. Stack with Ipamorelin for full GH-axis activation.
When to get off
Joint pain, water retention (puffy face, ring tightness), rising fasting glucose → cycle off immediately. Long-term continuous use shuts down natural GHRH production.
Administration
Side effects
Common
- Injection site reaction
- Flushing
- Tingling
Serious / theoretical
- Theoretical risks of chronic GH/IGF-1 elevation
Sources: PubMed
Further reading & listening
Where the experts go deeper.
Curated from the PeptideFacts expert directory — vetted YouTube channels, podcasts, books, and communities. No anecdote-only or supplier-affiliated picks.
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